Recombinant CD226 protein (His tag)

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Recombinant Human CD226 (DNAM-1) Fragment (aa 19-254) is a high-purity protein designed for studying immune cell adhesion and cytotoxicity. This fragment includes the complete Ig-like C2-type domains, making it an ideal tool for investigating receptor-ligand interactions and signaling pathways in NK and T-cell responses.

CD226 antigen (DNAM-1) is a critical cell surface receptor in the human immune system, primarily expressed on cytotoxic T-cells and NK cells. It functions as a costimulatory receptor that enhances cytotoxicity and lymphokine secretion upon binding to ligands PVR/CD155 or NECTIN2/CD112 on target cells such as virus-infected or tumor cells. Through phosphorylation by Src kinases, CD226 recruits adapter GRB2 to activate downstream effectors including VAV1, PI3K, PLCG1, ERK, and AKT, while also promoting calcium fluxes. The protein localizes to the cell membrane as a single-pass type I membrane protein and is enriched in lipid rafts, where it facilitates intercellular adhesion and lymphocyte signaling.