Recombinant CCNC protein (His tag)

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Recombinant Cyclin-C (cic-1) Fragment (1-302) from Caenorhabditis elegans: A high-purity protein fragment designed for studying the Cyclin N-terminal domain's role in transcriptional regulation. Ideal for investigating Mediator complex interactions and CDK activation mechanisms.

Cyclin-C, encoded by the cic-1 gene in C. elegans, is a critical component of the Mediator complex—a conserved coactivator that bridges gene-specific regulatory proteins with the RNA polymerase II transcription machinery. This complex facilitates assembly of the preinitiation complex and regulates transcription initiation. Cyclin-C activates CDK-8 to phosphorylate RNA polymerase II's C-terminal domain, potentially modulating transcription initiation. The protein localizes to the nucleus, consistent with its transcriptional role. The provided fragment (residues 1-302) contains the full Cyclin N-terminal domain, enabling targeted studies of domain-specific functions in cyclin-dependent kinase binding and Mediator complex recruitment.