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Product Name
CCL4 Polyclonal Antibody
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Description
Polyclonal antibody to CCL4
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Tested applications
WB, IHC
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Species reactivity
Human
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Alternative names
CCL4 antibody; ACT2 antibody; AT744.1 antibody; G-26 antibody; HC21 antibody; LAG-1 antibody; LAG1 antibody; MIP-1-beta antibody; MIP1B antibody; MIP1B1 antibody; SCYA2 antibody; SCYA4 antibody; C-C motif chemokine 4 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide corresponding to a sequence within amino acids 30 to the C-terminus of human CCL4 (NP_002975.1).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
IHC 1:50 - 1:200 -
Validations
Western blot - CCL4 Polyclonal Antibody
Western blot analysis of extracts of SGC-7901 cells, using CCL4 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
Immunohistochemistry - CCL4 Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human colon using CCL4 antibody at dilution of 1:100 (40x lens).
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Background
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"