Recombinant CAR14 protein (His tag)

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Recombinant Human CARD14 (Caspase recruitment domain-containing protein 14) Fragment (aa 1-407) - A high-purity protein fragment specifically designed to encompass the complete CARD domain (aa 15-107), providing researchers with an essential tool for studying inflammatory signaling pathways and domain-specific functions.

CARD14 functions as a critical scaffolding protein that activates key inflammatory signaling pathways, including NF-kappa-B and p38/JNK MAP kinase cascades. The protein forms a signaling complex with BCL10 and MALT1, where it activates MALT1 proteolytic activity and drives inflammatory gene expression. Research demonstrates that MALT1 is indispensable for CARD14-induced activation of both NF-kappa-B and MAP kinase pathways. Additionally, CARD14 may participate in signaling mediated by TRAF2, TRAF3, and TRAF6, and exhibits protective effects against apoptosis. The protein localizes to the cytoplasm across its isoforms, with isoform 3 potentially functioning as a dominant negative regulator of NF-kappa-B activation. This recombinant fragment provides researchers with a targeted tool to investigate the specific functions of the CARD domain within these complex signaling networks.