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Product Name
Recombinant CALB2 protein (His tag)
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Description
Recombinant Calretinin (CR) (29 kDa calbindin) fragment (amino acids 1-271) from Homo sapiens, encompassing all six EF-hand calcium-binding domains. This high-purity protein is an essential tool for investigating calcium homeostasis, neuronal signaling, and synaptic plasticity mechanisms in research applications.
Calretinin (encoded by CALB2) is a calcium-binding protein crucial for maintaining intracellular calcium homeostasis and modulating calcium-dependent signal transduction pathways. It functions as a calcium buffer and influences synaptic plasticity and neuronal excitability, contributing to learning and memory processes. During embryonic development, Calretinin supports neuronal differentiation and maturation. The protein is localized to synapses, dendrites, and specialized dendritic structures, particularly in specific neuronal populations. This recombinant fragment preserves the complete functional architecture of Calretinin's EF-hand domains, enabling targeted studies of calcium buffering and signaling functions.
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Protein name
Calretinin
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Uniprot ID
P22676
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Gene Name
CALB2; CAB29
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-271 aa (P22676) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 33.20 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 37 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"