-
Product Name
Recombinant CACB3 protein (His tag)
- Documents
-
Description
Recombinant Human Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) fragment (residues 33-363) is a high-purity protein designed for studying the SH3 domain's role in regulating L-type calcium channels. This 331-amino acid fragment serves as an essential tool for investigating calcium channel function and modulation in neuronal and cardiac research.
The full-length Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) functions as a regulatory subunit of voltage-gated calcium channels that generate L-type calcium currents. It enhances peak calcium currents through CACNA1B and CACNA1C channels while modulating their voltage-dependent activation and inactivation properties. This protein is primarily localized in the cytoplasm, where it plays crucial roles in calcium signaling pathways essential for various physiological processes, including muscle contraction and neurotransmitter release.
-
Protein name
Voltage-dependent L-type calcium channel subunit beta-3
-
Uniprot ID
P54284
-
Gene Name
CACNB3; CACNLB3
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 33-363 aa (P54284) were fused with 6His tag.
-
Protein Species
Human
-
Molecular weight
Predictes a molecular mass of 39.16 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 40 kDa band.
-
Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"