Human CCL5/RANTES (His & mucin Tag) recombinant protein
Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokin ligand 5(CCL5) is chemotactic for T cells, basophils and eosinophils. Chemokin ligand 5(CCL5) has been considered a HIV-supressor secreted by CD8+ T cells and other immune cells. Chemokin ligand 5(CCL5) is a key to activating recruit leukocytes into inflammatory sites and in the presence of particular cytokines released by T cells, it can change the NK cells into CHAK cells.
C-C motif chemokine
Protein short names
EOCP; SCYA5; MGC17164; MURANTES; SISD; RANTES; TCP228; SIS-DELTA; CCL5; D17S136E
A DNA sequence encoding the human RANTES (NP_002976.2) (Met 1-Ser 91) was fused with the C-terminal polyhistidine-tagged human Fractalkine mucin-stalk (Phe 101-Gln 341) at the C-terminus.
The recombinant human RANTES/Mucin stalk chimera consists of 318 amino acids and has a predicted molecular mass of 34 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh RANTES/Mucin stalk chimera is approximately 50-80 kDa due to glycosylation.
> 95 % as determined by SDS-PAGE
Human CCL5 / RANTES Protein (His & mucin Tag) SDS-PAGE
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