Brevinin-1AN1 peptide

Brevinin-1AN1 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-FLTGVLKLASKIPSVLCAVLKTC-OH

H-Phe-Leu-Thr-Gly-Val-Leu-Lys-Leu-Ala-Ser-Lys-Ile-Pro-Ser-Val-Leu-Cys-Ala-Val-Leu-Lys-Thr-Cys-OH

23

95.85%

C₁₁₁H₁₉₄N₂₆O₂₈S₂

2405

Synthetic

Powder

Brevinin-1AN1 is an antimicrobial peptide (AMP) that was purified from the skin secretions of the frog species Babina daunchina.
Brevinin-1AN1 belongs to the brevinin-1 family of AMPs and has been found to possess higher antimicrobial activity against Gram-positive bacteria compared to Gram-negative bacteria.
Brevinin-1AN1 exhibits a considerable tendency to form a stable amphipathic α-helical conformation, with hydrophilic amino acids concentrated on one side of the helix and hydrophobic amino acids segregated on the other side. The formation of a single intramolecular disulfide bond by two cysteine residues in Brevinin-1AN1 contributes to its structural stability.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Hu Y, Xu S, Hu Y, et al. Diverse families of antimicrobial peptides isolated from skin secretions of three species of East Asian frogs, Babina daunchina, Babina adenopleura, and Rana omeimontis (Ranidae). Zool Sci. 2014;31(7):438-44.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.