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Product Name
Recombinant BRDT protein (His tag)
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Description
Recombinant Human BRDT Bromodomain Fragment (1-141) is a high-purity protein fragment encompassing the complete Bromo 1 domain of the Bromodomain testis-specific protein (BRDT/CT9). This fragment is specifically engineered for investigating histone recognition, chromatin remodeling, and gene regulation mechanisms in spermatogenesis research.
The full-length Bromodomain testis-specific protein (BRDT), also known as Cancer/testis antigen 9, is a testis-specific chromatin protein that plays crucial roles in spermatogenesis. It specifically binds to acetylated histone H4 at Lys-5 and Lys-8 (H4K5ac and H4K8ac) and is involved in both gene activation during meiosis and histone removal during post-meiotic phases. BRDT also recognizes butyrylated histones and participates in mRNA processing and chromocenter organization. Located exclusively in the nucleus and associated with chromatin, BRDT serves as a key regulator of chromatin dynamics during male germ cell development, making it an important target for reproductive biology and epigenetic research.
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Protein name
Bromodomain testis-specific protein
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Uniprot ID
Q58F21
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Gene Name
BRDT
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-141 aa (Q58F21) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 18.17 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 18 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"