Recombinant BRD9 protein (His tag)

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Recombinant Human BRD9 (Bromodomain-containing protein 9) Fragment (aa 138-241) is a high-purity, stable protein designed for chromatin remodeling and transcription regulation studies. This 104-amino acid fragment offers a soluble and structurally defined unit ideal for biochemical assays, structural analysis, and epigenetic research.

Bromodomain-containing protein 9 (BRD9), also known as Rhabdomyosarcoma antigen MU-RMS-40.8, is a nuclear protein that functions as a chromatin reader and remodeling factor. It recognizes and binds acylated histones, including acetylated and butyrylated forms, playing a key role in regulating transcription. As a component of the SWI/SNF chromatin remodeling subcomplex GBAF, BRD9 contributes to ATP-dependent alterations in chromatin structure by modifying DNA-histone contacts. Additionally, it facilitates homologous recombination by orchestrating the formation of the RAD51-RAD54 complex. The protein is localized exclusively in the nucleus, underscoring its central role in nuclear processes and epigenetic mechanisms.