Recombinant BRD7 protein (His tag)

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This recombinant protein product features a 169-amino acid fragment (residues 312-480) of human Bromodomain-containing protein 7 (BRD7), also known as Protein CELTIX-1. The fragment is designed to provide a stable and soluble unit ideal for structural studies, biochemical assays, and functional investigations related to BRD7's roles in chromatin remodeling and transcriptional regulation.

Bromodomain-containing protein 7 (BRD7) is a multifunctional nuclear protein involved in both coactivation and corepression of transcription, with key roles in chromatin remodeling. It acts as an activator of the Wnt signaling pathway by negatively regulating GSK3B phosphotransferase activity and promoting dephosphorylation of GSK3B at Tyr-216. BRD7 also functions as a transcriptional corepressor, binding to target promoters such as ESR1 and increasing histone H3 acetylation at Lys-9 (H3K9ac). Additionally, it serves as a coactivator for TP53-mediated transcription, facilitating TP53 acetylation at Lys-382 and recruitment to promoters, which is essential for cell-cycle arrest in response to oncogene activation. BRD7 inhibits G1 to S phase progression and down-regulates TRIM24-mediated activation of the androgen receptor. The protein is localized to the nucleus and chromosomes, underscoring its importance in nuclear processes and gene expression regulation.