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Product Name
Recombinant BRD1 protein (His tag)
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Description
Recombinant Human BRD1 Fragment (451-758) is a high-purity protein designed for studying the bromodomain of Bromodomain-containing protein 1. This fragment encompasses the functional bromodomain (residues 562-666), making it an ideal tool for investigating histone acetyltransferase complex interactions, chromatin remodeling, and hematopoiesis regulation in research applications.
Bromodomain-containing protein 1 (BRD1), encoded by the BRD1 gene in Homo sapiens, functions as a scaffold subunit in histone acetyltransferase (HAT) complexes, including the MOZ/MORF and HBO1 complexes. It plays a critical role in hematopoiesis by directing KAT7/HBO1 specificity toward histone H3 Lys-14 acetylation (H3K14ac), thereby promoting erythroid differentiation. The protein localizes to the nucleus and chromosomes, specifically at transcription start sites, underscoring its importance in epigenetic regulation and gene expression control. This recombinant fragment allows focused analysis of its bromodomain-mediated functions without interference from other protein regions.
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Protein name
Bromodomain-containing protein 1
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Uniprot ID
O95696
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Gene Name
BRD1; BRL; BRPF2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 451-758 aa (O95696) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 37.94 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 40 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"