Recombinant BPNT1 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

This recombinant protein product features a stable, soluble fragment (amino acids 2-308) of human 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT1), a key phosphatase enzyme involved in nucleotide and inositol phosphate metabolism. The carefully selected fragment maintains structural integrity and enzymatic functionality, making it ideal for biochemical assays, structural studies, and metabolic pathway research.

The full-length BPNT1 protein functions as a dual-specificity phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and hydrolyzes inositol 1,4-bisphosphate to inositol 4-phosphate. This enzyme plays a critical role in preventing toxic accumulation of PAP, which can inhibit various cellular enzymes including sulfotransferases and RNA processing proteins. Additionally, BPNT1 contributes to inositol recycling and phosphoinositide metabolism, making it essential for maintaining cellular homeostasis. The enzyme demonstrates substrate specificity, showing no activity toward 3'-AMP, inositol-1-phosphate, or inositol-1,4,5-triphosphate, highlighting its precise regulatory function in nucleotide and phosphoinositide signaling pathways.