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Product Name
Human ALK-3 / BMPR1A (His & Fc Tag) recombinant protein
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Description
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4. Positively regulates chondrocyte differentiation through GDF5 interaction (By similarity).
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Protein name
Bone morphogenetic protein receptor type-1A
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Protein short names
BMP type-1A receptor; BMPR-1A; ALK-3; SKR5
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Uniprot ID
P36894
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Gene Name
BMPR1A; ACVRLK3; ALK3
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Arg 152) of human ALK3 (NP_004320.2) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human ALK3/Fc is a disulfide-linked homodimeric protein after removal of the signal peptide. The reduced monomer consists of 376 amino acids and has a predicted molecular mass of 42 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh ALK3/Fc monomer is approximately 56 kDa due to glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
Measured by its ability to inhibit BMP4 induced activity in MC3T3-E1 Mouse osteoblastic cells. The ED50 for this effect is typically 0.1-0.3 μg/ml in the presence of 50 ng/mL of recombinant human BMP4.
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Validations
Human BMPRIA / ALK-3 / CD292 Protein (His & Fc Tag) SDS-PAGE
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