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Product Name
Recombinant BOD1 protein (His tag)
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Description
Recombinant Human BOD1 Protein Fragment (aa 43-185) - A high-quality recombinant protein representing a stable and soluble fragment of Biorientation of chromosomes in cell division protein 1 (FAM44B), essential for studying chromosome biorientation mechanisms in cell division.
BOD1 (Biorientation defective protein 1) is a crucial regulator of proper chromosome segregation during mitosis. The full-length protein functions in detecting and correcting syntelic attachments in mitotic spindles, ensuring accurate chromosome biorientation. BOD1 exhibits dynamic subcellular localization, residing at centrosomes throughout the cell cycle (dissociating only during cytokinesis) and localizing at kinetochores from prometaphase until anaphase. This spatial and temporal regulation underscores its critical role in maintaining genomic stability during cell division processes.
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Protein name
Biorientation of chromosomes in cell division protein 1
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Uniprot ID
Q96IK1
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Gene Name
BOD1; FAM44B
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 43-185 aa (Q96IK1) were fused with 6His tag.
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Sequence
43-185
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 17.62 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 18 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"