Recombinant BMX protein (His tag)

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Recombinant Human Cytoplasmic Tyrosine-Protein Kinase BMX (EC 2.7.10.2) Fragment (aa 290-675) – a highly functional protein fragment ideal for investigating the specific roles of the SH2 and Protein Kinase domains in signaling pathways related to cell migration, proliferation, and survival.

Cytoplasmic tyrosine-protein kinase BMX is a non-receptor tyrosine kinase that modulates diverse signaling processes, including actin reorganization, cell migration, proliferation, survival, adhesion, and apoptosis. It participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors, and integrins. BMX is critical in TNF-induced angiogenesis and is implicated in the signaling of TEK and FLT1 receptors, which are essential for angiogenesis. It also activates STAT3 for cell differentiation, contributes to interleukin-6-induced differentiation, and supports adaptive cytoprotection against extracellular stress in salivary epithelial, brain endothelial, and dermal fibroblast cells. Additionally, BMX may regulate endocytosis via interaction with RUFY1 and plays roles in hematopoietic cell growth and differentiation, as well as in endocardial and arterial endothelial cell signaling. Subcellularly, BMX is localized in the cytoplasm and at the edges of spreading cells when complexed with BCAR1.