Recombinant BMP6 protein (His tag)

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Recombinant Human BMP-6 Fragment (aa 409-513) is a highly stable and soluble protein fragment derived from Bone Morphogenetic Protein 6, designed for structural and biochemical research. This 105-amino acid fragment retains key features ideal for investigating BMP-6's roles in bone formation, iron metabolism regulation, and TGF-beta signaling pathways.

Bone Morphogenetic Protein 6 (BMP-6) is a crucial growth factor within the TGF-beta superfamily, playing essential roles in developmental processes including cartilage and bone formation. It significantly regulates iron metabolism by acting as a ligand for hemojuvelin (HJV) to modulate HAMP/hepcidin expression. BMP-6 initiates canonical signaling through ACVR1 and ACVR2B receptors, leading to SMAD1/5/8 phosphorylation and transcriptional regulation, and also engages non-canonical pathways like TAZ-Hippo signaling to influence VEGF signaling via VEGFR2 expression. As a secreted protein, BMP-6 functions extracellularly, making it accessible for therapeutic and research applications targeting bone disorders and iron homeostasis.