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  • BMAP-28 (BMAP28)

BMAP-28 (BMAP28)

Cat.#: 300621

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Optional Service: TFA RemovalWhat's this?

Special Price 248.9 USD

Availability: 3 weeks
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Product Information

  • Product Name
    BMAP-28 (BMAP28)
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    GGLRSLGRKILRAWKKYGPIIVPIIRIG
  • Three letter code
    H-Gly-Gly-Leu-Arg-Ser-Leu-Gly-Arg-Lys-Ile-Leu-Arg-Ala-Trp-Lys-Lys-Tyr-Gly-Pro-Ile-Ile-Val-Pro-Ile-Ile-Arg-Ile-Gly-OH
  • Length (aa)
    28
  • Peptide Purity (HPLC)
    96.0
  • Molecular Formula
    C147H252N44O31
  • Molecular Weight
    3131.8
  • Source
    Synthetic
  • Additional Information
    Active against E. coli, S. typhimurium, P. aeruginosa, S. marcescens, S. aureus (MRSA), S. epidermidis, B. megaterium (MIC 0.5-4 uM), C. albicans, and C. neoformans (MIC 4-8 uM). BMAP-28 has broad antimicrobial activities and confers protection in an animal model:mouse of bacterial infection or sepsis (Giacometti A et al. 2004 Crit Care Med 32, 2485-90). Furthermore, BMAP-28 and its isomers demonstrated anti-leishmanial activities against intracellular L. major amastigotes within a macrophage infection model. Interestingly, the D-amino acid form is more active against parasites than either BMAP-28 (the L form) or the sequence reversed form (Lynn MA et al 2011 PLoS Negl Trop Dis. 5(5):e1141). Trucation of the C-terminal tail reduced hemolysis. Of note, a modified peptide (mBMAP-28) was also synthesized by replacing the C-terminal hydrophobic tail (residues 20-28) with a more hydrophilic sequence QATPATRQ also reduced peptide cell selectivity. Updated 7/2011. BMAP-28 (BMAP28) has Antibacterial, Antifungal activity. The source of BMAP-28 (BMAP28) is Cow Bos taurus.
  • Storage Guidelines
    Ideally BMAP-28 (BMAP28) should be stored in a freezer at or below -9C. BMAP-28 (BMAP28) should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M. Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. J Biol Chem. 1996;271(45):28375-81.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

  • Analysed Sequence:H-GGLRSLGRKILRAWKKYGPIIVPIIRIG-OH
  • Chemical Formula:C147H252N44O31
  • Sequence length:28
  • Extinction coefficient:6970 M-1cm-1
  • GRAVY:0.23
  • Mw average:3131.84
  • Theoretical pI:12.41
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

Red: Hydrophobic uncharged residues, like F I L M V W A and P

Blue: Basic residues, like R K H and N-terminal -NH2

Green: Acidic residues, like D E and C-terminal -COOH

Black: Polar uncharged residues, like G S T C N Q and Y

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"