Recombinant BID protein (His tag)

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Recombinant Human BH3-interacting domain death agonist (BID) Fragment (residues 82-195) is a high-purity protein fragment designed for structural and biochemical studies. This 114-amino acid segment includes key functional domains and offers excellent stability and solubility, making it ideal for apoptosis research, caspase activation assays, and mitochondrial signaling investigations.

BH3-interacting domain death agonist (BID) is a crucial regulator of apoptosis in human cells. The full-length protein induces caspase activation and programmed cell death while countering the protective effects of BCL2. Following cleavage, BID generates active fragments including p15 BID, which translocates to mitochondrial membranes and facilitates cytochrome c release. BID primarily localizes to the cytoplasm in its uncleaved form, with cleaved fragments targeting mitochondrial outer membranes. This protein plays a central role in connecting death receptor signaling to mitochondrial apoptosis pathways, making it essential for understanding cell death mechanisms in both normal physiology and disease states.

82-195