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Product Name
Recombinant BGBP2 protein (His tag)
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Description
Recombinant Drosophila melanogaster Gram-negative bacteria-binding protein 2 (GNBP2) fragment (residues 21-461) is a high-purity protein designed for studying innate immune recognition. This 441-amino acid fragment contains the complete CBM39 and GH16 functional domains, making it an ideal tool for investigating beta-1,3-glucan binding and phenoloxidase cascade activation mechanisms.
Gram-negative bacteria-binding protein 2 (GNBP2) from Drosophila melanogaster plays a critical role in innate immunity by recognizing invading microorganisms. The protein specifically binds to beta-1,3-glucan and activates the phenoloxidase cascade, an important defense mechanism against pathogens. According to its subcellular localization, GNBP2 is a secreted protein, allowing it to function in extracellular immune surveillance. The full-length protein's ability to detect microbial components makes it a key molecule in understanding pattern recognition receptor systems in invertebrate immunity.
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Protein name
Gram-negative bacteria-binding protein 2
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Uniprot ID
Q9VVR4
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Gene Name
GNBP2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 21-461 aa (Q9VVR4) were fused with 6His tag.
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Protein Species
Drosophila melanogaster
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Molecular weight
Predictes a molecular mass of 52.13 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 54 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"