Recombinant BAX protein (His tag)

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Recombinant Human BAX (Apoptosis Regulator BAX) Fragment (1-171) is a high-quality protein product designed for structural and biochemical studies. This fragment represents a stable and soluble unit of the full-length BAX protein, which plays a central role in regulating mitochondrial apoptosis. Ideal for researchers investigating programmed cell death mechanisms, this recombinant protein offers reliability and consistency for in vitro applications.

BAX (Bcl-2-like protein 4) is a key regulator of the mitochondrial apoptotic pathway in humans. Under normal cellular conditions, BAX remains primarily cytosolic through retrotranslocation from mitochondria mediated by BCL2L1/Bcl-xL, preventing toxic accumulation at mitochondrial membranes. During cellular stress, BAX undergoes conformational changes that trigger its translocation to the mitochondrial outer membrane, where it facilitates cytochrome c release and subsequent activation of caspase-3, ultimately initiating apoptosis. The protein localizes to multiple cellular compartments including the mitochondrial outer membrane (isoform Alpha), cytoplasm (isoforms Alpha, Beta, Gamma, and Delta), and nucleus (isoform Alpha), with its subcellular distribution and function being tightly regulated by interactions with partner proteins and post-translational modifications.