Recombinant BACH1 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human BACH1 Fragment (1-130) is a high-purity protein designed for studying the BTB domain of the transcription regulator BACH1. This fragment provides researchers with a targeted tool to investigate domain-specific functions in transcriptional regulation and oxidative stress response pathways.

BACH1 (BTB and CNC homolog 1) is a human transcriptional regulator that functions as either a repressor or activator depending on cellular context. It binds to NF-E2 DNA binding sites and plays a crucial role in coordinating transcription through interaction with MAFK. Notably, BACH1 forms a repressive complex with MAF to suppress genes in the NFE2L2 oxidative stress pathway, making it significant in cellular stress response mechanisms. The protein is localized to the nucleus, where it exerts its regulatory functions. The provided fragment (amino acids 1-130) contains the complete BTB domain (residues 34-100), enabling focused studies on this specific functional region.