Recombinant BACE1 protein (His tag)

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Recombinant Human Beta-secretase 1 (BACE1) Fragment (residues 57-457) is a high-quality protein preparation encompassing the complete Peptidase A1 domain. This fragment provides researchers with a functional tool for studying the enzymatic activity and molecular mechanisms of BACE1, a key protease involved in amyloid precursor protein processing and Alzheimer's disease pathology.

Beta-secretase 1 (BACE1) is a membrane-associated aspartic protease responsible for the proteolytic processing of the amyloid precursor protein (APP). It cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leading to the generation and extracellular release of beta-cleaved soluble APP and a corresponding cell-associated C-terminal fragment that is subsequently processed by gamma-secretase. BACE1 is predominantly localized to the Golgi apparatus and trans-Golgi network, with additional presence in the endoplasmic reticulum, endosomes, cell surface, and various cytoplasmic vesicle membranes. The enzyme also demonstrates localization in lysosomes, late endosomes, early endosomes, and recycling endosomes, and undergoes retrograde transport from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1-dependent manner. BACE1 plays a critical role in neuronal development and function, with additional demonstrated activity in cleaving CHL1.