Recombinant AXIN1 protein (His tag)

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Explore the Axin-1 (hAxin) Recombinant Protein Fragment (residues 78-246), a high-purity human-derived protein that encompasses the critical RGS domain. This fragment is an essential tool for researchers investigating Wnt signaling regulation, beta-catenin degradation, and cellular growth pathways, offering targeted insights into domain-specific molecular mechanisms.

Axin-1 (Axis inhibition protein 1), encoded by the AXIN1 gene in Homo sapiens, is a multifunctional scaffold protein central to the beta-catenin destruction complex. It regulates CTNNB1 levels through phosphorylation and ubiquitination, thereby modulating Wnt signaling—a pathway critical for embryonic development, cell proliferation, and tumor suppression. Axin-1 also enhances TGF-beta signaling by promoting SMAD7 degradation and forms part of the AXIN1-HIPK2-TP53 complex, which governs cell growth, apoptosis, and stress responses such as UV-induced DNA damage. Localized to the cytoplasm, nucleus, and membrane, Axin-1's dynamic subcellular distribution underscores its role in diverse cellular processes, including dorsoventral patterning and JNK pathway activation.