Recombinant ATRX protein (His tag)

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Recombinant Human ATRX Fragment (aa 2000-2428) is a high-purity protein designed for studying the Helicase C-terminal domain's role in chromatin remodeling, transcriptional regulation, and telomere maintenance. This fragment provides an essential tool for investigating ATP-dependent helicase activity and DNA replication mechanisms in targeted research applications.

The full-length ATRX protein (UniProt ID: P46100) is a crucial transcriptional regulator and chromatin remodeler in humans, functioning as an ATP-dependent helicase. It plays key roles in DNA replication, telomere structural integrity, and histone H3.3 deposition through the ATRX:DAXX complex. ATRX binds G-rich DNA regions, including quadruplex structures, and participates in allele-specific gene expression at imprinted loci such as IGF2/H19. Localized primarily in the nucleus, it associates with pericentromeric heterochromatin, telomeres, and PML bodies, interacting with partners like CBX5/HP1α to stabilize chromatin. Its functions extend to brain development, facial morphogenesis, and regulating H3K9me3 levels at zinc-finger genes, underscoring its broad significance in epigenetic regulation and genomic stability.

2000-2428