Recombinant ATP5J protein (His tag)

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Recombinant Human ATP synthase peripheral stalk subunit F6 (ATP5PF) fragment (residues 33-108), a key mitochondrial protein component essential for ATP production. This 76-amino acid fragment has been carefully selected for optimal stability and solubility, making it ideal for structural studies and functional investigations of the mitochondrial ATP synthase complex.

ATP synthase peripheral stalk subunit F6 is a crucial component of the mitochondrial membrane ATP synthase complex (Complex V), which generates ATP from ADP using the proton gradient created by the respiratory chain. This enzyme complex consists of a soluble F1 catalytic domain and a membrane-embedded F0 proton channel domain, connected by both a rotating central stalk and a stationary peripheral stalk. Subunit F6 forms part of the F0 domain and the peripheral stalk, functioning as a stator that maintains the catalytic alpha3beta3 subcomplex and subunit a/ATP6 in a fixed position relative to the rotating elements during ATP synthesis. The protein is localized to the mitochondrial inner membrane, where it plays an essential role in oxidative phosphorylation and cellular energy production.