Recombinant ATF4 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Introducing the Recombinant Human ATF4 bZIP Domain Fragment (aa 260-351), a high-purity protein fragment designed for studying the DNA-binding and dimerization functions of the Activating Transcription Factor 4. This 92-amino acid fragment fully encompasses the critical bZIP domain, making it an ideal tool for researchers investigating transcriptional regulation, stress response pathways, and protein-DNA interactions.

ATF4 (Activating Transcription Factor 4) is a master regulator of cellular stress responses and metabolic processes in human cells. This transcription factor binds cAMP response elements (CREs) and serves as a core effector of the integrated stress response (ISR), adapting cells to endoplasmic reticulum stress, amino acid starvation, mitochondrial stress, and oxidative stress. Under normal conditions, ATF4 regulates essential processes including bone development, synaptic plasticity, and circadian rhythm. The protein localizes primarily to the nucleus and nuclear speckles, where it functions as both a transcriptional activator and repressor. The bZIP domain contained within this fragment is responsible for DNA binding and protein dimerization, critical for ATF4's function in stress adaptation and metabolic regulation.