Recombinant AT1A3 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Sodium/Potassium-Transporting ATPase Subunit Alpha-3 (ATP1A3) Fragment (residues 329-762) is a high-purity, stable protein fragment designed for structural and biochemical studies. This 434-amino acid fragment retains key properties of the catalytic subunit, offering researchers a soluble and functional tool to investigate ion transport mechanisms and ATPase activity.

The full-length Sodium/Potassium-Transporting ATPase Subunit Alpha-3 is a catalytic component of the Na+/K+ ATPase enzyme complex, which hydrolyzes ATP to exchange sodium and potassium ions across the plasma membrane. This activity establishes essential electrochemical gradients that drive active nutrient transport and maintain cellular homeostasis. The protein is localized to the cell membrane as a multi-pass transmembrane protein, playing a critical role in numerous physiological processes, including neuronal excitability and ion balance. The provided fragment (residues 329-762) was computationally selected to represent a stable, soluble region, enabling detailed mechanistic studies without membrane-associated complexities.