Recombinant ASGR2 protein (His tag)

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Introducing the recombinant human Asialoglycoprotein receptor 2 (ASGP-R 2) fragment (amino acids 80-311), a high-quality protein designed for functional studies. This 232-amino acid fragment fully encompasses the C-type lectin domain, making it an ideal tool for investigating galactose and N-acetylgalactosamine recognition, endocytosis mechanisms, and carbohydrate-binding activities in hepatic research.

The full-length Asialoglycoprotein receptor 2 (ASGR2) is a key mediator in glycoprotein clearance, specifically recognizing and internalizing plasma glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues after sialic acid removal. As a single-pass type II membrane protein located in the cell membrane, it facilitates ligand binding, complex internalization, and receptor recycling through sorting organelles. This receptor plays a crucial role in hepatic glycoprotein metabolism and endocytic pathways, making it significant for studies of liver function, carbohydrate recognition, and cellular uptake mechanisms.