Recombinant ASAH1 protein (His tag)

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Recombinant Human Acid Ceramidase (ASAH1) Fragment (aa 143-395) is a high-purity, stable protein fragment designed for structural and biochemical studies. This 253-amino acid segment retains key functional regions, offering researchers a soluble and active unit ideal for investigating ceramide metabolism and sphingolipid signaling pathways.

Acid ceramidase (ASAH1) is a lysosomal enzyme that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at acidic pH, playing a crucial role in sphingolipid metabolism. This enzyme regulates bioactive lipids involved in cell proliferation, apoptosis, and differentiation, with particular importance in keratinocyte differentiation and steroidogenesis. The full-length protein is primarily localized to lysosomes through mannose-6-phosphate receptor-dependent targeting and demonstrates both hydrolytic and synthetic activities toward various ceramide substrates. The selected fragment (aa 143-395) represents a computationally optimized stable domain that maintains structural integrity for research applications.