Recombinant ARL4C protein (His tag)

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Recombinant ADP-ribosylation factor-like protein 4C (ARL4C) fragment (residues 2-192) from Homo sapiens, a stable and soluble GTP-binding protein unit ideal for structural studies and biochemical assays investigating intracellular transport and membrane dynamics.

ADP-ribosylation factor-like protein 4C is a small GTP-binding protein that cycles between inactive GDP-bound and active GTP-bound states, regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). It plays a critical role in vesicular transport between perinuclear compartments and the plasma membrane, particularly in the ABCA1-mediated cholesterol secretion pathway. ARL4C recruits CYTH1-4 proteins to the plasma membrane in its GDP-bound form and regulates microtubule-dependent vesicular transport from early to recycling endosomes. The protein localizes to the cell membrane, cytoplasm, and filopodia, underscoring its involvement in cellular trafficking and membrane dynamics.