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Product Name
Human ALOX15B / 15 Lipoxygenase 2 recombinant protein
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Description
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.
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Protein name
Arachidonate 15-lipoxygenase B
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Protein short names
SECOND TYPE; ALOX15B; 8S-LOX; 15-LOX-2; 15-LOX-B; ARACHIDONATE 8-LIPOXYGENASE; 8-LOX; ARACHIDONATE 15-LIPOXYGENASE 2; ARACHIDONATE 15-LIPOXYGENASE; RP23-26L6.5; ARACHIDONATE 15-LIPOXYGENASE B; 15-LIPOXYGENASE 2; TYPE B; ARACHIDONATE 15-LIPOXYGENASE TYPE II; ALOX8; 8S-LIPOXYGENASE; 15S-LIPOXYGENASE; ARACHIDONATE OMEGA(6) LIPOXYGENASE
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Uniprot ID
O15296
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Gene Name
ALOX15B
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human ALOX15B (AAH35217.1)( Met1-Ile676) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
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Protein Species
Human
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Molecular weight
The secreted recombinant human ALOX15B consists of 678 amino acids and predicts a molecular mass of 76 KDa. The apparent molecular mass of the protein is approximately 62-66 KDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human ALOX15B / 15 Lipoxygenase 2 Protein SDS-PAGE
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