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  • APGWamide-related peptide 3

APGWamide-related peptide 3

Not For Human Use, Lab Use Only.

Cat.#: 313200

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Product Information

  • Product Name
    APGWamide-related peptide 3
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    RPGW-amide
  • Sequence
    H-Arg-Pro-Gly-Trp-NH2
  • Length (aa)
    4
  • Peptide Purity (HPLC)
    96.96%
  • Molecular Formula
    C24H35N9O4
  • Molecular Weight
    513.59
  • Source
    Synthetic
  • Form
    Powder
  • Description

    APGWamide-related peptide 3 is a neuropeptide identified in the mollusk cephalopod Sepia officinalis through LC-ESI-MS/MS analysis. This peptide is part of a family of tetrapeptides, including APGWamide, TPGWamide, RPGWamide, and KPGWamide, which are derived from two distinct genes previously cloned in Lymnaea stagnalis and Mytilus edulis. APGWamide-related peptides are processed by a dipeptidyl aminopeptidase (DPAP) in the central nervous system (CNS), leading to the formation of the dipeptide GWamide. Tissue mapping reveals that APGWamide is present in both the CNS and nerve endings, while TPGWamide and GWamide are exclusively localized in the CNS.

    The differential processing efficiency of these peptides by DPAP varies, with APGWamide being the most efficiently processed (44.7%), followed by RPGWamide (24.3%), KPGWamide (19.3%), and TPGWamide (11.7%). The presence and distribution of these peptides suggest their involvement in diverse physiological functions, particularly in neural and peripheral signaling pathways. The absence of RPGWamide and KPGWamide in Sepia officinalis tissues indicates potential complete processing into GWamide, highlighting the role of DPAP in neuropeptide modulation.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Henry J, Zatylny C. Identification and tissue mapping of APGWamide-related peptides in Sepia officinalis using LC-ESI-MS/MS. Peptides. 2002;23(6):1031-7.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"