Recombinant AP2A1 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant AP-2 complex subunit alpha-1 (AP2A1) fragment (residues 735-977) from Homo sapiens, designed for structural and biochemical studies. This 243-amino acid fragment offers a stable, soluble unit ideal for investigating clathrin-mediated endocytosis mechanisms and adaptor protein interactions.

The full-length AP-2 complex subunit alpha-1 is a critical component of the adaptor protein complex 2 (AP-2), which functions in clathrin-dependent endocytosis by mediating cargo selection and vesicle formation at the plasma membrane. It recognizes specific endocytosis signal motifs (Y-X-X-Φ and [ED]-X-X-X-L-[LI]) in transmembrane cargo proteins and serves as a scaffolding platform for endocytic accessory proteins through its C-terminal appendage domain. Located at the cell membrane in coated pits, AP-2 facilitates receptor-mediated endocytosis and synaptic vesicle recycling, with implications in neuronal plasticity and membrane trafficking pathways. This recombinant fragment provides a focused tool for exploring these essential cellular processes without domain-specific constraints.