Recombinant ANXA2 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Annexin A2 (ANXA2) Fragment (residues 2-339) is a high-quality, stable protein designed for structural and biochemical studies. This fragment encompasses the full-length functional domain, offering a soluble and well-folded unit ideal for investigating calcium-regulated membrane binding, plasmin generation, and interactions with PCSK9 or microbial toxins.

Annexin A2 is a calcium-regulated membrane-binding protein that plays critical roles in cellular processes such as heat-stress response, endosomal membrane stabilization, and fibrinolytic surveillance. It binds two calcium ions with high affinity and is involved in inhibiting PCSK9-enhanced LDLR degradation, potentially modulating cholesterol metabolism. Additionally, Annexin A2 serves as a receptor for pathogens like Mycoplasma pneumoniae CARDS toxin, contributing to infection mechanisms. The protein localizes to the extracellular space, basement membrane, and melanosomes, and is translocated to the cell surface via a Golgi-independent pathway, highlighting its importance in membrane dynamics and cellular defense.