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Product Name
Anti-VDAC1 Rabbit antibody
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Description
VDAC1 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P
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Species reactivity
Human, Mouse, Rat
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Alternative names
PORIN; VDAC-1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human VDAC1
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/2000
IHC: 1/20-1/500
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Validations
Western blot detection of VDAC1 in 293 cell lysates using VDAC1 Rabbit pAb(1:1000 diluted).Predicted band size:31KDa.Observed band size:31KDa.
Immunohistochemistry of VDAC1 in paraffin-embedded Human colon cancer tissue using VDAC1 Rabbit pAb at dilution 1/50
Western blot detection of VDAC1 in Jurkat,Rat Brain,C6 cell lysates using VDAC1 Rabbit pAb(1:1000 diluted).Predicted band size:31kDa.Observed band size:31kDa.
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Background
Swiss-Prot Acc.P21796.Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"