Anti-TNFRSF11A antibody

Anti-TNFRSF11A antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human TNFRSF11A

WB, ICC/IF, IF, IP

Human TNFRSF11A

CD265 antibody; FEO antibody; LOH18CR1 antibody; Ly109 antibody; mRANK antibody; ODFR antibody; ODFR antibody; OFE antibody; OFE antibody; OPTB7 antibody; osteoclast differentiation factor receptor antibody; OSTS antibody; PDB2 antibody; Rank antibody; RANK antibody; receptor activator of NF-kappaB antibody; receptor activator of NF-KB antibody; TRANCE-R antibody; TRANCER antibody; tumor necrosis factor receptor superfamily member 11A antibody; TNFRSF11A antibody; TNFRSF11A antibody

Rabbit IgG

Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human TNFRSF11A, and purified by antigen affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. Defects in TNFRSF11A can cause familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.