Anti-Syndecan-1/SDC1/CD138 antibody

Anti-Syndecan-1/SDC1/CD138 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to Syndecan-1/SDC1/CD138

WB, IHC-P

Human Syndecan-1 / SDC1 / CD138

CD138 antibody; CD138 antibody; SDC1 antibody; Sstn antibody; syndecan antibody; Syndecan-1 antibody; Syndecan-1 antibody; SDC antibody; CD138 antibody; SYND1 antibody; syndecan antibody; Sstn antibody; Synd antibody; CD138 antibody; Synd1 antibody; syn-1 antibody; AA408134 antibody; AA409076 antibody; AA408134 antibody; AA409076 antibody; SDC antibody; Sdc1 antibody; syn-1 antibody; Synd antibody; Synd1 antibody; SYND1 antibody; syndecan antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human Syndecan-1 / SDC1 / CD138 (rh Syndecan-1 / SDC1 / CD138; NP_002988.3; Met 1-Glu 251). Syndecan-1 / SDC1 / CD138 specific IgG was purified by Human Syndecan-1 / SDC1 / CD138 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

• Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.
• Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.
• Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.