Anti-Smad3 antibody

Anti-Smad3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to Smad3

WB, IP

human SMAD3

MAD antibody; SMAD antibody; Madh3 antibody; AU022421 antibody; LDS3 antibody; LDS1C antibody; MADH3 antibody; JV15-2 antibody; HSPC193 antibody; HsT17436 antibody; AU022421 antibody; hMAD-3 antibody; hSMAD3 antibody; HSPC193 antibody; HsT17436 antibody; JV15-2 antibody; LDS1C antibody; LDS3 antibody; MAD homolog 3 antibody; MAD homolog 3 antibody; mad homolog JV15-2 antibody; mad protein homolog antibody; mad3 antibody; mad3 antibody; MADH3 antibody; Madh3 antibody; mMad3 antibody; mothers against decapentaplegic homolog 3 antibody; mothers against decapentaplegic homolog 3 antibody; mothers against DPP homolog 3 antibody; mothers against DPP homolog 3 antibody; RP23-63E8.1 antibody; SMA- and MAD-related protein 3 antibody; Smad 3 antibody; SMAD family member 3 antibody; SMAD family member 3 antibody; SMAD3 antibody; Smad3 antibody

Rabbit IgG

Produced in rabbits immunized with A synthetic peptide corresponding to the center region of the human SMAD3, and purified by antigen affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is involved in cell signalling. It modulates signals of activin and TGFβ's. Binding of SMAD3 with SMAD4 enables its transmigration into the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD3 is a receptor-regulated SMAD (R-SMAD). In mice, mutation of SMAD3 has been linked to colorectal adenocarcinoma, increased systemic inflammation, and accelerated wound healing. Increased SMAD3 activity has been implicated in the pathogenesis of scleroderma. Smad3 is also a multifaceted regulator in adipose physiology and the pathogenesis of obesity and type 2 diabetes.

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• Feng X. et al., 1996, Nature. 383 (6596): 168-72.