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  • Anti-S100A12 antibody

Anti-S100A12 antibody

Cat.#: 102823

Special Price 145.0 USD

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Product Information

  • Product Name
    Anti-S100A12 antibody
  • Documents
  • Description
    Rabbit polyclonal to S100A12
  • Tested applications
    ELISA, IHC-P
  • Species reactivity
    Human S100A12 / CAGC
  • Alternative names
    CGRP antibody; CAAF1 antibody; CAGC antibody; ENRAGE antibody; EN-RAGE antibody; MRP6 antibody; p6 antibody; S100A12 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human S100A12 (rh S100A12; NP_005612.1; Met 1-Glu 92). S100A12 specific IgG was purified by human S100A12 affinity chromatography
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human S100A12. The detection limit for Human S100A12 is approximately 0.00245 ng/well.

    IHC-P: 0.1-1 μg/mL

  • Validations

    S100A12 / CAGC Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    S100A12 / CAGC Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    Immunochemical staining of human S100A12 in human spleen with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections).

  • Background
    S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A12, also known as S100 calcium-binding protein A12, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, and S100A12, is a member of the S-101 family. Like the majority of S100 proteins, S100A12 is a dimer, with the interface between the two subunits being composed mostly of hydrophobic residues. The fold of S100A12 is similar to the other known crystal and solution structures of S100 proteins, except for the linker region between the two EF-hand motifs. S100A12 plays an important role in the inflammatory response.
  • References
    • Moroz, OV. et al., 2001, Acta Crystallogr D Biol Crystallogr. 57: 20-9.
    • Foell, D. et al., 2003, Lancet  361 (9365):1270-2.
    • Vogl, T. et al., 2004, Blood. 104: 4260-8.
    • Viemann, D. et al., 2005, Blood. 105: 2955-62.
    • Nakatani, Y. et al., 2005, Mediators Inflamm. 2005: 280-292.
    • Bjoerk, P. et al., 2009, PLoS Biol. 7: E97-E97.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"