Anti-PTPRJ antibody

Anti-PTPRJ antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Mouse PTPRJ

IHC-P

Mouse DEP1 / PTPRJ

CD148 antibody; CD148 antigen antibody; density enhanced phosphatase-1 antibody; density-enhanced phosphatase 1 antibody; DEP1 antibody; DEP-1 antibody; DEP-1 antibody; HPTP eta antibody; HPTPeta antibody; human density enhanced phosphatase-1 antibody; J polypeptide antibody; protein tyrosine phosphatase antibody; protein-tyrosine phosphatase eta antibody; protein-tyrosine phosphatase receptor type J antibody; rCG_26744 antibody; receptor type antibody; receptor-type tyrosine-protein phosphatase eta antibody; R-PTP-ETA antibody; R-PTP-J antibody; SCC1 antibody; DEP1 antibody; SCC1 antibody; CD148 antibody; HPTPeta antibody; R-PTP-ETA antibody; BET antibody; Byp antibody; Scc1 antibody; CD148 antibody; DEP-1 antibody; Ptpb2 antibody; RPTPJ antibody; Scc-1 antibody; AI450271 antibody; PTPbeta2 antibody

Rabbit IgG

Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Mouse DEP1 / PTPRJ, and purified by antigen affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 / PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. DEP1 / PTPRJ is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. In stable MCF-7 cell lines lines, induction of DEP-1 expression inhibited breast cancer cell growth by 5-10-fold. These data describe PTPs expressed and regulated in breast cancer cell lines during differentiation and identify one PTP, DEP-1, that inhibits the growth of breast cancer cells in vitro.