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Product Name
Anti-PTPN6 antibody
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Description
Rabbit polyclonal to PTPN6
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Tested applications
ELISA, WB, IP
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Species reactivity
Mouse PTPN6
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Alternative names
SHP-1 antibody; protein tyrosine phosphatase antibody; HCP antibody; protein tyrosine phosphatase antibody; HCPH antibody; SHP-1 antibody; HPTP1C antibody; PTP-1C antibody; SHP-1L antibody; SH-PTP1 antibody; me antibody; hcp antibody; Hcph antibody; Ptp1C antibody; 70Z-SHP antibody; SH-PTP1 antibody; PTPTY-42 antibody; SHP1 antibody; SHP-1 antibody; 70Z-SHP antibody; HCP antibody; hcp antibody; Hcph antibody; HCPH antibody; hematopoietic cell phosphatase antibody; hematopoietic cell protein-tyrosine phosphatase antibody; hematopoietic cell protein-tyrosine phosphatase antibody; hemopoietic cell phosphatase antibody; HPTP1C antibody; me antibody; motheaten antibody; non-receptor type 6 antibody; non-receptor type 6 antibody; protein-tyrosine phosphatase 1C antibody; protein-tyrosine phosphatase 1C antibody; protein-tyrosine phosphatase SHP-1 antibody; Ptp1C antibody; PTP-1C antibody; PTP-1C antibody; Ptpn6 antibody; PTPN6 antibody; PTPTY-42 antibody; SHP1 antibody; SHP-1 antibody; SHP-1L antibody; SH-PTP1 antibody; SH-PTP1 antibody; tyrosine-protein phosphatase non-receptor type 6 antibody; tyrosine-protein phosphatase non-receptor type 6 antibody
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Mouse PTPN6 (rM PTPN6; P29351-2; Ala207-Lys597). PTPN6 specific IgG was purified by Mouse PTPN6 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 5-10 μg/ml
ELISA: 0.1-0.2 μg/ml
This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Mouse PTPN6.
IP: 1-4 μg/mg of lysate
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Background
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"