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Product Name
Anti-PTEN Rabbit antibody
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Description
PTEN Rabbit polyclonal antibody
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Tested applications
WB
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Species reactivity
Rat, Mouse
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Alternative names
10q23del;BZS;DEC;GLM2;MGC11227;MHAM;MMAC1;MMAC1 phosphatase and tensin homolog deleted on chromosome 10;Mutated in multiple advanced cancers 1;Phosphatase and tensin homolog;Phosphatase and tensin like protein;Phosphatidylinositol-3,4,5-trisphosphate 3-ph antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: CDHYRYSDTTDSDP
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Clonality
Polyclonal
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Formulation
10mM PBS with 0.02% sodium azide 50% glycerol.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000
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Validations
Western blot detection of PTEN in C6 and 3T3 cell lysates using PTEN Rabbit pAb (dilution 1:1000).Predicted band size:47kDa.Observed band size:54kDa.
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Background
Swiss-Prot Acc.P60484.Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"