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Anti-PPM1A (1D2) Mouse antibody

Cat.#: 168307

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-PPM1A (1D2) Mouse antibody
  • Documents
  • Description
    PPM1A (1D2) Mouse monoclonal antibody
  • Tested applications
    WB, FC
  • Species reactivity
    Human, Monkey
  • Isotype
    Mouse IgG1
  • Preparation
    Antigen: Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. Coli.
  • Clonality
    Monoclonal
  • Formulation
    Purified antibody in PBS with 0.05% sodium azide
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/500 - 1/2000

    FC: 1/200 - 1/400

    ELISA: 1/10000

  • Validations

    Flow cytometric analysis of HeLa cells using PPM1A mouse mAb (green) and negative control (red).

    Flow cytometric analysis of HeLa cells using PPM1A mouse mAb (green) and negative control (red).

    Western blot analysis using PPM1A mouse mAb against Jurkat (1), Jurkat (2), A431 (3), HeLa (4), HEK293 (5), Raji (6), MCF-7 (7), and COS7 (8) cell lysate.

    Western blot analysis using PPM1A mouse mAb against Jurkat (1), Jurkat (2), A431 (3), HeLa (4), HEK293 (5), Raji (6), MCF-7 (7), and COS7 (8) cell lysate.

    Western blot analysis of extracts from Raji,HCT116,Jurkat and MCF7 cell lysates using PP2C-u03b1 mouse mAb (1:1000 diluted).Predicted band size:43KDa.Observed band size:43KDa.

    Western blot analysis of extracts from Raji,HCT116,Jurkat and MCF7 cell lysates using PP2C-u03b1 mouse mAb (1:1000 diluted).Predicted band size:43KDa.Observed band size:43KDa.

  • Background
    Swiss-Prot Acc.P35813.The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"