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Product Name
Anti-PP2A alpha/beta Rabbit antibody
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Description
PP2A alpha/beta Rabbit polyclonal antibody
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Tested applications
WB, ICC/IF, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
RP-C; PP2Ac; PP2CA; PP2Calpha antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human PP2A alpha
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
ICC/IF: 1/20-1/100
FC: 1/20-1/100
IP: 1/50
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Validations
Western blot detection of PP2A alpha/beta in K562,Rat Brain,C6,3T3 cell lysates using PP2A alpha/beta Rabbit pAb(1:1000 diluted).Predicted band size:36kDa.Observed band size:36kDa.
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Background
Swiss-Prot Acc.P67775.PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I . Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"