-
Product Name
Anti-PMVK / phosphomevalonate kinase antibody
- Documents
-
Description
Rabbit polyclonal to PMVK / phosphomevalonate kinase
-
Tested applications
ELISA, IHC-P
-
Species reactivity
Human PMVK / phosphomevalonate kinase
-
Alternative names
PMK antibody; PMKA antibody; PMKASE antibody; HUMPMKI antibody; PMK antibody; PMKA antibody; PMKASE antibody; AV001327 antibody; 1110011E12Rik antibody; 2900002L22Rik antibody; phosphomevalonate kinase antibody; Pmvk antibody; 1110011E12Rik antibody; 2900002L22Rik antibody; AV001327 antibody; PMK antibody; PMKA antibody; PMKASE antibody
- Immunogen
-
Isotype
Rabbit IgG
-
Preparation
Produced in rabbits immunized with purified, recombinant Human PMVK / phosphomevalonate kinase (rh PMVK / phosphomevalonate kinase; Q15126; Met1-Leu192). PMVK / phosphomevalonate kinase specific IgG was purified by Human PMVK / phosphomevalonate kinase affinity chromatography.
-
Clonality
Polyclonal
-
Formulation
0.2 μm filtered solution in PBS
-
Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
ELISA:0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human PMVK / phosphomevalonate kinase. The detection limit for Human PMVK / phosphomevalonate kinase is < 0.039 ng/well.
IHC-P: 0.1-2 μg/ml
-
Validations
PMVK / phosphomevalonate kinase Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
PMVK / phosphomevalonate kinase Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
PMVK / phosphomevalonate kinase Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
PMVK / phosphomevalonate kinase Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
-
Background
PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of PMVK is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"