Anti-PIGR antibody

Anti-PIGR antibody

• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to PIGR

IHC-P

Human PIGR

class R antibody; FLJ22667 antibody; MGC125361 antibody; MGC125362 antibody; OTTMUSP00000025847 antibody; phosphatidylinositol glycan antibody; PIGR antibody; Pigr antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human PIGR (rh PIGR; NP_002635.2; Met1-Arg638,365Ser/Gly).

Monoclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Polymeric immunoglobulin receptor, also known as PIGR, is a member of the immunoglobulin superfamily and a Fc receptor. The ectodomain of this receptor consists of five units with homology to the variable units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions. PIGR is expressed on several glandular epithelia including those of liver and breast. The deduced amino-acid sequence has a length of 764 residues and shows an overall similarity of 56% and 64% with the rabbit and rat counterpart. PIGR mediates transcellular transport of polymeric immunoglobulin molecules, and thus facilitates the secretion of IgA and IgM. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment of PIGR.

• Coyne, R. S. et al., 1995, J. Biol. Chem. 269 (50) :31620-31625. 
• Kaetzel,C.S., 2001,  Curr Biol. 11(1): R35-38.