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Anti-PI 3 Kinase catalytic subunit gamma/PI3K-gamma (2D10) Mouse antibody

Cat.#: 168331

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Product Information

  • Product Name
    Anti-PI 3 Kinase catalytic subunit gamma/PI3K-gamma (2D10) Mouse antibody
  • Documents
  • Description
    PI 3 Kinase catalytic subunit gamma/PI3K-gamma (2D10) Mouse monoclonal antibody
  • Tested applications
    WB
  • Species reactivity
    Human
  • Isotype
    Mouse IgG1
  • Preparation
    Antigen: Purified recombinant fragment of human PIK3CG (AA: 1-100) expressed in E. Coli.
  • Clonality
    Monoclonal
  • Formulation
    Purified antibody in PBS with 0.05% sodium azide.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/500 - 1/2000

    ELISA: 1/10000

  • Validations

    Western blot analysis using PIK3CG mAb against HEK293 (1) and PIK3CG (AA: 1-100)-hIgGFc transfected HEK293 (2) cell lysate.

    Western blot analysis using PIK3CG mAb against HEK293 (1) and PIK3CG (AA: 1-100)-hIgGFc transfected HEK293 (2) cell lysate.

    Western blot analysis of extracts from Jurkat cell lysates using PI3 Kinase p110u03b3 mouse mAb (1:500 diluted).Predicted band size:126KDa.Observed band size:110KDa.

    Western blot analysis of extracts from Jurkat cell lysates using PI3 Kinase p110u03b3 mouse mAb (1:500 diluted).Predicted band size:126KDa.Observed band size:110KDa.

  • Background
    Swiss-Prot Acc.P48736.This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"