Anti-Phospho-ATF2 (Thr71) Rabbit antibody

Cat.#: 166822

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Product Information

  • Product Name
    Anti-Phospho-ATF2 (Thr71) Rabbit antibody
  • Documents
  • Description
    Phospho-ATF2 (Thr71) Rabbit polyclonal antibody
  • Tested applications
    WB, ICC/IF, IP
  • Species reactivity
    Human, Mouse
  • Alternative names
    HB16; CREB2; TREB7; CREB-2; CRE-BP1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic phosphopeptide corresponding to residues surrounding Thr71 of human ATF2
  • Clonality
    Polyclonal
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/1000

    ICC/IF: 1/100

    IP: 1/20

  • Validations

    Western blot detection of Phospho-ATF2 (Thr71) in 3T3,Hela cell lysates using Phospho-ATF2 (Thr71) Rabbit pAb(1:1000 diluted).Predicted band size:55kDa.Observed band size:70kDa.

    Western blot detection of Phospho-ATF2 (Thr71) in 3T3,Hela cell lysates using Phospho-ATF2 (Thr71) Rabbit pAb(1:1000 diluted).Predicted band size:55kDa.Observed band size:70kDa.

  • Background
    Swiss-Prot Acc.P15336.Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"