Anti-phospho-Amyloid Precursor Protein (Thr743) Rabbit antibody

Anti-phospho-Amyloid Precursor Protein (Thr743) Rabbit antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

phospho-Amyloid Precursor Protein (Thr743) Rabbit monoclonal antibody

WB, ICC/IF, IP

Human, Mouse, Rat

IgG

Antigen: A synthetic phosphopeptide corresponding to residues surrounding Thr743 of human Amyloid Precursor Protein

Monoclonal

50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA

Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]